Cadmium-Induced Cell Homeostasis Impairment is Suppressed by the Tor1 Deficiency in Fission Yeast.
Identifieur interne : 000139 ( Main/Exploration ); précédent : 000138; suivant : 000140Cadmium-Induced Cell Homeostasis Impairment is Suppressed by the Tor1 Deficiency in Fission Yeast.
Auteurs : Miroslava Požgajová [Slovaquie] ; Alica Navrátilová [Slovaquie] ; Eva Šebová [République tchèque] ; Marek Kovár [Slovaquie] ; Miroslava Ka Niová [Slovaquie, Pologne]Source :
- International journal of molecular sciences [ 1422-0067 ] ; 2020.
Abstract
Cadmium has no known physiological function in the body; however, its adverse effects are associated with cancer and many types of organ system damage. Although much has been shown about Cd toxicity, the underlying mechanisms of its responses to the organism remain unclear. In this study, the role of Tor1, a catalytic subunit of the target of rapamycin complex 2 (TORC2), in Cd-mediated effects on cell proliferation, the antioxidant system, morphology, and ionome balance was investigated in the eukaryotic model organism Schizosaccharomyces pombe. Surprisingly, spectrophotometric and biochemical analyses revealed that the growth rate conditions and antioxidant defense mechanisms are considerably better in cells lacking the Tor1 signaling. The malondialdehyde (MDA) content of Tor1-deficient cells upon Cd treatment represents approximately half of the wild-type content. The microscopic determination of the cell morphological parameters indicates the role for Tor1 in cell shape maintenance. The ion content, determined by inductively coupled plasma optical emission spectroscopy (ICP-OES), showed that the Cd uptake potency was markedly lower in Tor1-depleted compared to wild-type cells. Conclusively, we show that the cadmium-mediated cell impairments in the fission yeast significantly depend on the Tor1 signaling. Additionally, the data presented here suggest the yet-undefined role of Tor1 in the transport of ions.
DOI: 10.3390/ijms21217847
PubMed: 33105893
PubMed Central: PMC7660220
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Niova, Miroslava" sort="Ka Niova, Miroslava" uniqKey="Ka Niova M" first="Miroslava" last="Ka Niová">Miroslava Ka Niová</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fruit Science, Viticulture and Enology, Faculty of Horticulture and Landscape Engineering, Slovak University of Agriculture in Nitra, 94976 Nitra, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Fruit Science, Viticulture and Enology, Faculty of Horticulture and Landscape Engineering, Slovak University of Agriculture in Nitra, 94976 Nitra</wicri:regionArea><wicri:noRegion>94976 Nitra</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Bioenergetics, Food Analysis and Microbiology, Institute of Food Technology and Nutrition, University of Rzeszow, 35-601 Rzeszow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Bioenergetics, Food Analysis and Microbiology, Institute of Food Technology and Nutrition, University of Rzeszow, 35-601 Rzeszow</wicri:regionArea><wicri:noRegion>35-601 Rzeszow</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of molecular sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cadmium has no known physiological function in the body; however, its adverse effects are associated with cancer and many types of organ system damage. Although much has been shown about Cd toxicity, the underlying mechanisms of its responses to the organism remain unclear. In this study, the role of Tor1, a catalytic subunit of the target of rapamycin complex 2 (TORC2), in Cd-mediated effects on cell proliferation, the antioxidant system, morphology, and ionome balance was investigated in the eukaryotic model organism <i>Schizosaccharomyces pombe</i>. Surprisingly, spectrophotometric and biochemical analyses revealed that the growth rate conditions and antioxidant defense mechanisms are considerably better in cells lacking the Tor1 signaling. The malondialdehyde (MDA) content of Tor1-deficient cells upon Cd treatment represents approximately half of the wild-type content. The microscopic determination of the cell morphological parameters indicates the role for Tor1 in cell shape maintenance. The ion content, determined by inductively coupled plasma optical emission spectroscopy (ICP-OES), showed that the Cd uptake potency was markedly lower in Tor1-depleted compared to wild-type cells. Conclusively, we show that the cadmium-mediated cell impairments in the fission yeast significantly depend on the Tor1 signaling. Additionally, the data presented here suggest the yet-undefined role of Tor1 in the transport of ions.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">33105893</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>21</Issue><PubDate><Year>2020</Year><Month>Oct</Month><Day>22</Day></PubDate></JournalIssue><Title>International journal of molecular sciences</Title><ISOAbbreviation>Int J Mol Sci</ISOAbbreviation></Journal><ArticleTitle>Cadmium-Induced Cell Homeostasis Impairment is Suppressed by the Tor1 Deficiency in Fission Yeast.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E7847</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms21217847</ELocationID><Abstract><AbstractText>Cadmium has no known physiological function in the body; however, its adverse effects are associated with cancer and many types of organ system damage. Although much has been shown about Cd toxicity, the underlying mechanisms of its responses to the organism remain unclear. In this study, the role of Tor1, a catalytic subunit of the target of rapamycin complex 2 (TORC2), in Cd-mediated effects on cell proliferation, the antioxidant system, morphology, and ionome balance was investigated in the eukaryotic model organism <i>Schizosaccharomyces pombe</i>. Surprisingly, spectrophotometric and biochemical analyses revealed that the growth rate conditions and antioxidant defense mechanisms are considerably better in cells lacking the Tor1 signaling. The malondialdehyde (MDA) content of Tor1-deficient cells upon Cd treatment represents approximately half of the wild-type content. The microscopic determination of the cell morphological parameters indicates the role for Tor1 in cell shape maintenance. The ion content, determined by inductively coupled plasma optical emission spectroscopy (ICP-OES), showed that the Cd uptake potency was markedly lower in Tor1-depleted compared to wild-type cells. Conclusively, we show that the cadmium-mediated cell impairments in the fission yeast significantly depend on the Tor1 signaling. Additionally, the data presented here suggest the yet-undefined role of Tor1 in the transport of ions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Požgajová</LastName><ForeName>Miroslava</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navrátilová</LastName><ForeName>Alica</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Genetics and Breeding Biology, Faculty of Agrobiology and Food Resources Slovak University of Agriculture in Nitra, 94976 Nitra, Slovakia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Šebová</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Experimental Medicine, Czech Academy of Science, 14220 Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kovár</LastName><ForeName>Marek</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Plant Physiology, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, 94976 Nitra, Slovakia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kačániová</LastName><ForeName>Miroslava</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-4460-0222</Identifier><AffiliationInfo><Affiliation>Department of Fruit Science, Viticulture and Enology, Faculty of Horticulture and Landscape Engineering, Slovak University of Agriculture in Nitra, 94976 Nitra, Slovakia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Bioenergetics, Food Analysis and Microbiology, Institute of Food Technology and Nutrition, University of Rzeszow, 35-601 Rzeszow, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>APVV-17-0060</GrantID><Agency>Agentúra na Podporu Výskumu a Vývoja</Agency><Country></Country></Grant><Grant><GrantID>ITMS 26220220180</GrantID><Agency>Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Int J Mol Sci</MedlineTA><NlmUniqueID>101092791</NlmUniqueID><ISSNLinking>1422-0067</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ROS</Keyword><Keyword MajorTopicYN="N">Schizosccharomyces pombe</Keyword><Keyword MajorTopicYN="N">Tor1</Keyword><Keyword 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sort="Pozgajova, Miroslava" uniqKey="Pozgajova M" first="Miroslava" last="Požgajová">Miroslava Požgajová</name></noRegion><name sortKey="Ka Niova, Miroslava" sort="Ka Niova, Miroslava" uniqKey="Ka Niova M" first="Miroslava" last="Ka Niová">Miroslava Ka Niová</name><name sortKey="Kovar, Marek" sort="Kovar, Marek" uniqKey="Kovar M" first="Marek" last="Kovár">Marek Kovár</name><name sortKey="Navratilova, Alica" sort="Navratilova, Alica" uniqKey="Navratilova A" first="Alica" last="Navrátilová">Alica Navrátilová</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Sebova, Eva" sort="Sebova, Eva" uniqKey="Sebova E" first="Eva" last="Šebová">Eva Šebová</name></region></country><country name="Pologne"><noRegion><name sortKey="Ka Niova, Miroslava" sort="Ka Niova, Miroslava" uniqKey="Ka Niova M" first="Miroslava" last="Ka Niová">Miroslava Ka Niová</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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